| 毛建军 朱胜昌 朱培谦.胃癌组织中IGF-Ⅰ表达与LVD的关系[J].实用中西医结合临床,2008,(4):1-3 |
| 胃癌组织中IGF-Ⅰ表达与LVD的关系 |
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| DOI： |
| 中文关键词: 胃癌 胰岛素样生长因子-Ⅰ 淋巴管密度 淋巴管生成 |
| 英文关键词: Gastric carcinoma IGF-Ⅰ LVD lymphangiogenesis |
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| 中文摘要: |
| 目的：研究胃癌组织中胰岛素样生长因子Ⅰ表达与胃癌内淋巴管的关系及其意义。方法：运用RT-PCR的方法检测38例胃癌组织及15例正常胃组织中IGF-Ⅰ的表达情况，同时运用免疫组化检测其中的淋巴管及其密度。结果：IGF-ⅠmRNA在正常胃黏膜中有表达，但表达较少，而在胃癌组织中的表达比正常胃黏膜显著增高，正常组织中IGF-Ⅰ/GAPDH比值为（0.138±0.012），胃癌组织中IGF-Ⅰ/ GAPDH比值为（0.372±0.020），P <0.01。经统计学分析IGF-Ⅰ表达与胃癌临床分期（r=0.588, P < 0.01）、淋巴转移（r=0.493, P <0.05）正相关，与分化程度呈负相关（r=-0.462, P <0.01）；但与患者性别、年龄无关，均无统计学意义，P >0.05。胃癌组织淋巴管密度（LVD）平均（9.52±0.44）个，正常组织淋巴管密度平均（4.29±0.66）个；淋巴管密度与淋巴转移（r= 0.525, P <0.05）、临床分期（r=0.683, P <0.01）表达正相关，与分化程度负相关（r=-0.556, P <0.01），与IGF-Ⅰ的表达成显著正相关（r=0.732，P <0.001）；与正常胃组织有显著差异，P <0.001；与性别、年龄无关，不具有统计学意义，P>0.05。结论：胃癌组织IGF-Ⅰ表达及淋巴管密度与胃癌临床分期呈正相关，与分化程度呈负相关，与胃癌淋巴转移成正相关，与性别、年龄无关；IGF-Ⅰ与肿瘤淋巴管密度正相关；IGF-Ⅰ可能促进LVD、加速肿瘤的淋巴转移。 |
| 英文摘要: |
| Objective:To explore the relationship between the expression of IGF-Ⅰand LVD in gastric carcinoma.Methods:S-P immunohistochemical method and RT-PCR was applied in detecting carcinoma samples of 38 cases.Results:The expression of IGF-Ⅰwas positivily correlated with clinical stage（r=0.588, P <0.01）,and lympha node metastasis（r=0.493, P <0.05）,but was negatively correlated with pathologic differentiation（r=-0.462, P <0.01）.The expression of LVD was positivily correlated with clinical stage（r=0.683,P <0.01）,lympha node metastasis（r=0.525, P <0.05,and IGF-Ⅰ（r=0.732，P <0.001）,but was negatively correlated with pathologic differentiation（r=-0.556, P <0.05）.Conclusion:In gastric cancer, the expression rate of IGF-Ⅰand LVD was high. IGF-Ⅰ expression was positively correrated with LVD,and lympha node metastasis.It is presumed that IGF-Ⅰcan promote the metastasis of lyphma node in tumor by inducing LVD expression and the detection of IGF-Ⅰin gastic cancer tissues will be significance for prediction of progonsis. |
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