| 蒋太生 张晓春 蒋茂剑.益肾解毒合剂防治顺铂所致急性肾损害的临床研究[J].实用中西医结合临床,2007,(2):7-9 |
| 益肾解毒合剂防治顺铂所致急性肾损害的临床研究 |
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| DOI： |
| 中文关键词: 益肾解毒合剂 顺铂 急性肾损害 中医药疗法 防治作用 |
| 英文关键词: Yishen Jiedu mixture Cisplatin Acute Renal Damage TCM therapy Protective effect |
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| 中文摘要: |
| 目的：观察益肾解毒合剂对顺铂所致急性肾损害的防治作用。方法：82例恶性肿瘤患者随机分为化疗加益肾解毒合剂组（A组）和单纯化疗组(B组)，A组45例，B组37例。2组患者于疗前和疗后不同时期分别测定其尿微量白蛋白与肌酐的比值(mALB/Cr)、尿N-乙酰-β-D-氨基葡萄糖苷酶与肌酐比值(NAG/Cr)、尿β2微球蛋白与肌酐(β2-MG/ Cr)的比值、血尿素氮(BUN)和血清肌酐(SCr)。结果：A组2个疗程的第4、8、15天的尿mALB/Cr、NAG/Cr和β2-MG/ Cr的均值明显低于B组各对应点的值（P< 0.01）。A组2个疗程的第4天，BUN和SCr的均值低于B组（P <0.05），但其变化未超出正常值范围，第8、15天，2组两项指标与化疗前比较及相互比较，差异无显著性（P值均>0.05）。结论：益肾解毒合剂对顺铂所致急性肾损害有较好的防治作用。 |
| 英文摘要: |
| Objective:To evaluate protective effect of Yishen Jiedu mixture (YSJD) on the cisplatin (DDP)-induced acute renal damage. Methods:82 patients with malignancy were divided into two groups randomly: 45 in group A (treatment group) and 37 in group B(control group). The group A is treated by DDP-containing combination chemotherapy and YSJD. The group B is treated only by DDP-containing combination chemotherapy. The ratio of urinary micro-albumin and creatine (mALB/Cr), N-acetyl- beta-D-glucosaminidase and creatine (NAG/Cr), β2-microglobulin and creatine (β2-MG/ Cr), blood urea nitrogen (BUN) and serum cretinine (SCr) were monitored at different intervals before and after treatment. The study took 2 cycles,4 weeks each cycle. Results:In the 2 cycles of treatment in both groups, the values of urinary mALB/Cr, NAG/Cr and β2-MG/ Cr on d4,d8 and d15 in group A were obviously lower than those in group B(P <0.01). On d4 the values of BUN and SCr in group A were lower than those in group B(P <0.05) and no obvious difference of BUN and SCr was found on the other corresponding day between 2 groups. Conclusion:YSJD has protective effect on the (DDP)-induced acute renal damage. |
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