| 王欣 孙淑艳.糖尿病肾病患者血清可溶性细胞间黏附分子1检测的临床意义[J].实用中西医结合临床,2006,(5):12-13 |
| 糖尿病肾病患者血清可溶性细胞间黏附分子1检测的临床意义 |
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| DOI： |
| 中文关键词: 可溶性细胞间黏附分子1 糖尿病肾病 酶联免疫吸附法 分子水平测定 |
| 英文关键词: Soluble intercellular adhesion molecule -1 Diabetic nephropathy ELISA Molecular level mensuration |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨糖尿病肾病患者的血清sICAM-1水平在糖尿病肾病发生、发展过程中的作用及临床意义。方法：应用酶联免疫吸附法（ELISA）检测了60例2型糖尿病患者血清sICAM-1水平，并与30例健康人作对照, 且与空腹血糖、尿微量白蛋白进行相关分析。结果 ：2型糖尿病患者血清sICAM-1水平高于对照组，糖尿病肾病组高于糖尿病无肾病组，糖尿病无肾病组高于正常对照组，差异有显著意义 (P < 0. 01) , 且与空腹血糖、尿微量白蛋白等密切相关。结论：血清sICAM-1参与了糖尿病肾病的病变过程，可作为糖尿病肾病病情变化的监测指标。 |
| 英文摘要: |
| Objective：To study the change and significance of soluble intercellular adhesion molecule-1(sICAM -1) level in patients with type 2 diabetic nephropathy. Methods：The concentration of sICAM-1 in 60 cases of type 2 diabetes mellitus and 30 normal controls were detected with ELISA and combined with the levels of fasting blood glucose ( FBG) , urine micro album in (MA lb ) for correlation analysis. Results：sICAM -1 level in patients with diabetic nephropathy was higher than those in normal controls (P <0.01) and closely related to the levels of FBG,MA lb (P <0.01). Conclusion：Higher sICAM -1 level maybe contribute to the occurrence and development of diabetic nephropathy. |
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