| 蓝海兵.长春瑞滨联合顺铂治疗晚期非小细胞肺癌疗效观察[J].实用中西医结合临床,2006,(5):8-10 |
| 长春瑞滨联合顺铂治疗晚期非小细胞肺癌疗效观察 |
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| DOI： |
| 中文关键词: 非小细胞肺癌 长春瑞滨 顺铂 化疗 疗效观察 |
| 英文关键词: Non-small-cell lung cancer Vinorelbine Cisplatin Chemotherapy Curative effect Observation |
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| 中文摘要: |
| 目的：观察长春瑞滨（盖诺）联合顺铂（NP方案）治疗晚期非小细胞肺癌（NSCLC）的疗效及毒副作用。方法：42例经病理或细胞学诊断为非小细胞肺癌患者，采用国产长春瑞滨25mg/m2,第1、8天静滴；顺铂（DDP）60～80mg/m2，第1～3天静滴，28d为1个周期。结果 ：CR 3例，PR15例，SD16例，PD 8例，总有效率(CR+PR)为42.9%。主要毒副反应为白细胞减少及胃肠反应。结论：长春瑞滨联合顺铂治疗晚期NSCLC疗效确切，毒副反应可耐受。 |
| 英文摘要: |
| Objective：To observe the efficacy and toxicity of vinorelbine combined with cisplatin(NP regimen) in the treatment of advanced non-small-cell lung cancer(NSCLC).Methods：42 patients with advanced NSCLC were confirmed by pathology or cytology.NVB were used 25mg per centiare on days 1 and days 8；DDP were used 60 to 80 mg per centiare on days 1 to days 3，A Period includes 28 days.to evaluate the efficacy and toxicity after 2 periods at least.Results：Complete response was observed in 3 patients and partial response was observed in 15 patients.The overall response rate was 42.9%.The main tocicity was leucopenia and vomiting.Conclusions：The results indicate NP regimen for advanced NSCLC is promise,and the toxicities are tolerable. |
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