| 吴敏姣.米非司酮治疗子宫肌瘤68例临床分析[J].实用中西医结合临床,2006,(3):12-13 |
| 米非司酮治疗子宫肌瘤68例临床分析 |
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| DOI： |
| 中文关键词: 米非司酮 子宫肌瘤 孕激素 临床分析 |
| 英文关键词: Mifepriston Uterine Leimyoma Progesterone Clinical analysis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨米非司酮治疗子宫肌瘤的临床疗效。方法：子宫肌瘤68例口服米非司酮治疗，12.5mg，每日1次，睡前口服，连服3月；应用彩色超声监测治疗前后子宫肌瘤的变化，测定血清激素水平、肝肾功能、血红蛋白，观察服药后副反应。结果：68例患者在治疗期间均出现闭经，症状缓解。子宫体积平均缩小30.05%（P <0.01），肌瘤体积平均缩小44.56%（P <0.01）。治疗后E2、P平均水平较治疗前下降（P <0.01）。停药后34例患者子宫肌瘤逐渐增大，22例患者出现潮热、恶心等轻微副反应。结论：米非司酮治疗子宫肌瘤有一定疗效，副反应小，是一种有效的保守治疗方法，但停药后易复发。 |
| 英文摘要: |
| Objectives：To investigate the effects of mifepristone treating Uterine Leigmyoma. Methods：68 cases with uterine Leimyoma were treated with mifepristone , 12.5 mg once a day before sleeping for 3 months . To observed change of uterine Leimyoma pre-treatment and past-treatment by color Ultrasound and measured serous hormone levels, liver and renal function, and hemoglobin , meanwhile, the side effects of drugs were assessed.Results：68 patients were amenorrhea with hemoylobin increasing during treatment . The mean level of serous Estrogen and progesterone dropped after treatment (P <0.01) . The percentage of the mean cubaye of uterus and uterine leimoyoma diminished 30.05% (P <0.01) and 44.56% (P <0.01) . The volume of Leimyoma increased among 34 Patients after stoping treatment . The side effects such an flash and nausea appeared among 22 patients. Conclusions：Mifepristone is effective against uterine Leiomyma with less side effect . It’s anacceptable conserative therapy , but the clinical symptoms are easy to recur after stopping treatment. |
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