| 葛惠英.安达芬联合拉米呋啶治疗慢性乙型肝炎临床研究[J].实用中西医结合临床,2006,(2):13-14 |
| 安达芬联合拉米呋啶治疗慢性乙型肝炎临床研究 |
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| DOI： |
| 中文关键词: 安达芬 拉米呋啶 慢性乙型肝炎 不良反应 |
| 英文关键词: Anterferon Lamivudine Chronic hepatitis B Side effects |
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| 中文摘要: |
| 目的： 探讨安达芬联合拉米呋啶治疗慢性乙型肝炎的近期疗效及不良反应。方法： 选择116例慢性乙型肝炎患者，随机分成联合组（A组）40例，给予安达芬及拉米呋啶治疗。安达芬组（B组）38例，单用安达芬治疗；拉米呋啶组（C组）38例，单用拉米呋啶治疗。治疗结束时，观察3组患者肝功能、乙型肝炎病毒血清学标志（HBVM）的变化。结果： 3组患者血清谷丙转氨酶（ALT）均较治疗前显著下降，但A组明显高于B、C 2组，差异有显著性（P <0.05）；HBeAg阴转率分别为57.5%、42.1%和39.55，HBV-DNA阴转率分别为67.5%、47.4%和44.7%，A组的疗效明显优于B、C 2组（P <0.05），未见明显不良反应。结论： 安达芬联合拉米呋啶具有改善肝功能和抑制乙肝病毒复制等功效，两者联合应用可作为治疗慢性乙型肝炎的一种治疗方案，值得在临床推广。 |
| 英文摘要: |
| Objective ：To search out the short-term efficacy and side effects of chronic hepatitis B using Anterferon in combination with Lamivudine .Methods ：116 patients were randomly divided into three groups. 40 patients as group A was given Anterferon and Lamivudine,38 patients as group B was given single Anterferon ,38 Patients as group C was given single Lamivudine.After completion of therapy , the changment of liver function and HBVM were observed . Results ：ALT was decreased in this three groups . But group A was obviously higher than group B and group C （P <0.05）. The negative rate of HbeA was 57.5％ and 42.1％ and 39.5% . The negative rate of HBV-DNA was 67.5% and 47.4％ and 44.7% . Group A was higher than that of group B and group C （P <0.05）.Side effects had not been found . Conclusions ：Recombinant Anterferon in combination with Lamivudine can improve liver function and inhibit HBV . It is worth spreading as a clinical method . |
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