| 陆艳 宁瑶.肾盂肾炎患者尿视黄醇结合蛋白测定的临床意义[J].实用中西医结合临床,2006,(2):3-4 |
| 肾盂肾炎患者尿视黄醇结合蛋白测定的临床意义 |
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| DOI： |
| 中文关键词: retinal binding protein β2-MG pyelonephritis |
| 英文关键词: |
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| 中文摘要: |
| 目的：探索尿视黄醇结合蛋白（RBP）在肾盂肾炎患者诊疗中的临床意义。方法:40例经临床医生诊断为肾盂肾炎的患者,按肾小管间质损害程度分为2组：A组20例，肾小管间质活动指数（IAI）<3；B组20例，（IAI）≥3，并选择40例健康人作为对照组。用上海德波生物技术有限公司的试剂通过酶联免疫吸附试验测定病人和对照组的尿视黄醇结合蛋白和β2微球蛋白（β2-MG）的含量。结果：尿视黄醇结合蛋白水平在各组间的差异均有显著性(P <0.01)，其中B组升高更为显著。虽然B组的尿β2微球蛋白高于A组（P <0.05）和对照组（P <0.01），但A组与对照组差异无显著性(P >0.05)。结论：尿RBP可早期敏感的反映肾盂肾炎的损伤程度，且RBP敏感性高于β2-MG。 |
| 英文摘要: |
| Objective: To investigate the significance of determination of retinal binding protein (RBP) in patients with pyelonephritis. Methods: According to the degree of tubular interstitial impairment,40 cases that are diagnosed as pyelonephritis by clinical doctors are divided into two groups:group A(n=20,IAI<3),group B (n=20,IAI≥3) and we choose 40 healthy individuals as control group.Urinary levels of retinal binding protein (RBP) and β2 microglobulin (β2-MG) were measured by ELISA with the reagent from shanghai Debo Biotechnology Co.Ltd in all patients and 40 healthy individuals .Results:There was an obvious difference in urinary level of RBP among 3 groups (P <0.01) and the highest was that in group B.Thought urinary concentration of β2-MG in group B was much higher than that in group A(P <0.05) and control group(P <0.01) .But there was no difference between group A and control group (P >0.05) in the concentration of β2-MG.Conclusion:Compared withβ2-MG, detection of urinary RBP could be a relatively sensitive method for monitoring the degree of pyelonephritis. |
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