| 刘连升 胡岗.海螵蛸对尿毒症血透患者血磷和甲状旁腺素作用的研究[J].实用中西医结合临床,2005,(5):5-6 |
| 海螵蛸对尿毒症血透患者血磷和甲状旁腺素作用的研究 |
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| DOI： |
| 中文关键词: 肾性骨症 尿毒症 血透 血磷 甲状旁腺素 海螵蛸 |
| 英文关键词: Traditional Chinese medicine Endoconcha Sepiae Uremia, phosphorus parathyrin |
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| 中文摘要: |
| 目的：判定中药海螵蛸对尿毒症血透患者血磷和甲状旁腺素（PTH）的临床疗效。方法：将74例尿毒症血透治疗的病人，随机化分成对照组、海螵蛸治疗组和碳酸钙片治疗组。对照组不使用任何磷结合剂，海螵蛸治疗组采用海螵蛸3.0g在每餐中口服，碳酸钙组采用碳酸钙片1.5g在每餐中嚼服，各组观察期3个月。结果：采用海螵蛸作磷结合剂，与对照组和碳酸钙片组3组间比较治疗后血磷降低（P <0.01）、PTH水平降低（P <0.05）和血钙升高（P <0.05）；海螵蛸组治疗后与治疗前比较血磷降低（P <0.01）、PTH降低（P <0.05）；与碳酸钙片组比较在降低血磷效果优于碳酸钙组（P <0.05），降低PTH水平的疗效相当（P >0.05），对高血钙的影响较少（P <0.05）；海螵蛸组与对照组治疗后比较，有明显降低血磷（P <0.01）和PTH作用（P <0.01）。结论：中药海螵蛸中碳酸钙含量高，来源丰富，价格便宜，作为磷结合剂，替代碳酸钙和醋酸钙，可有效降低血磷，预防和治疗肾性骨病。 |
| 英文摘要: |
| Objectives:To assess the effect in Endoconcha Sepiae(a traditional Chinese medicine)to treat phosphorus and parathyrin in Uremia for hemodialysis.Methods:72 patients of Uremia for hemodialysis ware distinguished Control group and Calcium Carbonate group and Endoconcha Sepiae treatment group in Randmized principle.Control group not oral any phosphate binders.Endoconcha Sepiae group oral 3.0g Endoconcha Sepiae with meal.Calcium Carbonate group oral 1.5g Calcium Carbonate with meal.Every group has been observed with 3 month.Results:At the study with Endoconcha Sepiae as Phosphate binders,three group after treatment show that serum phosphorus decrease(P <0.01)and serum Calcium increase(P <0.05)and parathyrin decrease (P <0.05).Endoconcha Sepiae group Compare with Calcium Carbonate group show that serum phosphorus decrease(P <0.05)and that parathyrin is no change (P <0.05).Endoconcha Sepiae group Compare with Control group show that serum phosphorus and parathyrin decrease (P <0.01).Conclusion:Endoconcha Sepiae have more content of Calcium Carbonate and cheap and rich in sourse.As Phosphate binders for Uremia it can substiute for Calcium Careodystrophy. |
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