| 胡珂 甘淳 郑甦 高小翌.达立通颗粒治疗功能性消化不良的临床研究[J].实用中西医结合临床,2005,(5):3-4 |
| 达立通颗粒治疗功能性消化不良的临床研究 |
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| DOI： |
| 中文关键词: 达立通颗粒 功能性消化不良 中医药疗法 随机双盲对照试验 |
| 英文关键词: Dalitong granule Functional Dyspepsia Double-blind randomized controlled trial |
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| 中文摘要: |
| 目的：评价达立通颗粒治疗功能性消化不良的有效性和安全性。方法：选取功能性消化不良患者130例，随机分为达立通颗粒组（治疗组）86例和西沙比利片组（对照组）44例，进行分层区组随机对照双盲模拟试验。治疗组口服达立通颗粒+西沙比利片模拟剂；对照组口服西沙比利片+达立通颗粒模拟剂：疗程均为2周。结果：对中医证候疗效，治疗组总显效率65.44%，总有效率97.29%；对照组分别为61.66%、95.41%。2组中医证候疗效比较无统计学意义（P ＞0.05）。对痞满证候疗效而言，治疗组总显效率56.09%，总有效率94.74%；对照组分别为50.00%、88.75%。2组痞满证疗效比较无统计学意义（P ＞0.05）。胃排空试验显示，治疗组总显效率64.65%，总有效率95.83%；对照组分别为63.15%、96.43%。2组胃排空疗效比较无统计学意义（P ＞0.05）。在试验过程中，未发现明显不良反应。结论：达立通颗粒疗效与西沙比利相当，未发现明显的毒副作用。 |
| 英文摘要: |
| Objective：To assess the effect and safety of Dalitong Granule in the Treatment of Functional Dyspepsia. Methods：The double-blind, double-dummy and randomized controlled method was adopted. 130 patients were randomized to the treatment group (n=86) and the control group (n=44). The therapeutic course for both groups was 2 weeks. Results： In the treatment group ,the markedly effective rates and effective rates were 65.44% and 97.29% respectively. In the control group were 61.66% and 95.41% respectively. There was no significant difference between two groups（P ＞0.05）.For effects on Piman syndrome, in the treatment group ,the markedly effective rates and effective rates were 56.09% and 94.74% respectively. In the control group were 50.00% and 88.75% respectively. The results showed no statistical significant difference between two groups（P ＞0.05）.For effects on gastric emptying function, in the treatment group ,the markedly effective rates and effective rates were 64.65% and 95.83% respectively. In the control group were 63.15% and 96.43% respectively. There was no significant difference between two groups（P ＞0.05）.No adverse effect was found in the observation.Conclusion： Dalitong granule has the same clinical effect as cisapride with no obvious toxic-adverse effects. |
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