| 杨雄志 张庆珍.“水三仙”口服液对小鼠免疫性肝损伤保护作用的研究[J].实用中西医结合临床,2005,(3):7-8 |
| “水三仙”口服液对小鼠免疫性肝损伤保护作用的研究 |
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| DOI： |
| 中文关键词: “水三仙”口服液 卡介苗 脂多糖 免疫性肝损伤 保肝作用 |
| 英文关键词: SSL BCG LPS Immunological liver injury hepatoprotection |
| 基金项目: |
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| 摘要点击次数: 670 |
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| 中文摘要: |
| 目的：探讨“水三仙”口服液(SSL)对卡介苗(BCG)和脂多糖(LPS)诱导的小鼠免疫性肝损伤的保护作用。方法:静脉注射BCG和LPS诱导小鼠免疫性肝损伤。在注射LPS前，小鼠腹腔注射不同剂量的SSL(10、15、20 mL/kg），连续10d后，取血清，检测血清谷丙转氨酶（ALT）、谷草转氨酶（AST）、乳酸脱氢酶（LDH）的活性，测定肝组织匀浆中脂质过氧化产物丙二醛（MDA）含量和超氧化物歧化酶（SOD）活性。结果： 不同剂量的SSL治疗组小鼠血清ALT、AST、LDH活性及肝组织匀浆MDA含量均低于模型组，且肝组织损伤不同程度地减轻。结论：“水三仙”口服液对BCG和LPS诱导的小鼠免疫性肝损伤具有一定的保护作用。 |
| 英文摘要: |
| objective：To study the protective effect of Oral Shuishanxian Liquor ( SSL) on experimental liver injury induced by Calmette-Guerin bacillus vaccine (BCG) and Lipopolysaccharide ( LPS ) in mice.Methods：Experimental liver injury was induced by Calmette-Guerin bacillus vaccine and Lipopolysaccharide in male mice by injecting via tail vein (50 μg/kg ), and administering LPS ( 10μg/mouse ) 10d later. Therapeutic groups were given respectively with SSL (10,15,20 ml/kg) before administration of LPS. The level of ALT, AST and LDH in serum were measured by automatic biochemistry analyzer, and MDA in liver plasma was measured by TBA method and the level of SOD was measured by pymgallol autooxidation method. Results：The three experimental groups were found with significant decrease in the elevation of serum GPT and LDH level and the content of MDA in the liver plasma. The liver tissue damages were also ameliorated. Conclusion： SSL has protective effect against the experimental liver injury induced by BCG and LPS in mice. |
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