| 尹满香 林雪平 方铣华 陶正义.nm23-H1、PCNA、p53蛋白在肺多形性癌组织中的表达及意义[J].实用中西医结合临床,2005,(3):5-7 |
| nm23-H1、PCNA、p53蛋白在肺多形性癌组织中的表达及意义 |
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| DOI： |
| 中文关键词: 肺肿瘤 nm23-H1蛋白 PCNA蛋白 p53蛋白 预后 |
| 英文关键词: lung tumor nm23-H1 protein PCNA protein P53 protein prognosis |
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| 中文摘要: |
| 目的：探讨nm23-H1、PCNA、p53蛋白在肺多形性癌组织中的表达及意义。方法：应用免疫组化SP法回顾性分析20例肺多形性癌组织中nm23-H1、PCNA、p53基因表达，并结合肺多形性癌的转移、侵袭力、肿块大小及预后等进行分析。结果： nm23-H1在肺多形性癌有无淋巴结转移中阳性率分别为25.0%和87.5%，差异有显著性（P ＜0.01），有无侵犯周围组织中阳性率各为37.5%和100%，差异有显著性（P ＜0.01）；PCNA在肺多形性癌有无淋巴结转移中阳性率分别为66.7%和75.0%，差异无显著性（P ＞0.05），在有无侵犯周围组织中阳性率各为68.8%和75.0%，差异无显著性（P ＞0.05）；p53在肺多形性癌有无淋巴结转移中阳性率分别为83.3%和25.0%，差异有显著性（P ＜0.01），在有无周围组织中阳性率各为68.8%和25.0%，差异有显著性（P ＜0.01）。Nm23-H1、p53基因表达与肺多形性癌淋巴结转移、侵袭力及预后有关。结论：m23-H1、P53基因能抑制肺多形性癌的转移及侵袭，而PCNA基因表达与肺多形性癌的转移和侵袭无明确相关性。 |
| 英文摘要: |
| Objective: To observe the expression and role of nm23-H1、PCNA and P53 protein in lung polymorphic cancer tissue. Methods:The expression of nm23-H1、PCNA and P53 in lung polymorphic cancer were determined by immunohistochemistry, and combined the results with metastasis、 invasiveness、tumor and prognosis of lung polymorphic cancer, then compated study. Results:The positive rates of nm23-H1、PCNA and P53 in lung polymorphic cancer tissues with and without lymphatic metastasis were 25.0% and 87.5% 、66.7% and 75.0%、83.3%and 25.0% respectively, In lung polymorphic cancer with and without invasive peripheral tissue, the posivive rates were 37.5% and 100%、68.8% and 75.0%、68.8% and 25.0% resptctively , The nm23-H1 and P53 had obvious difference (P <0.01), but PCNA had not difference (P >0.05). The expression of nm23-H1 and P53 were closely related with the lymphatic metastasis、invasisveness and prognosis of lung Polymorphic cancer. Conciusions：nm23-H1 and P53 gene can effectively inhibit metastasis and invasiveness of lung polymorphic cancer , but the PCNA can not do it. |
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