| 罗勇 成汉荣.地中海贫血对瑞芬太尼复合异丙酚靶控静脉麻醉的影响[J].实用中西医结合临床,2005,(1):10-11 |
| 地中海贫血对瑞芬太尼复合异丙酚靶控静脉麻醉的影响 |
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| DOI： |
| 中文关键词: 哌啶类 二异丙酚 地中海贫血 药物投与系统 可行性研究 |
| 英文关键词: piperidines Propofol Thalassanenia Drug delivery systems Feasibility studies |
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| 中文摘要: |
| 目的：观察地中海贫血对瑞芬太尼复合异丙酚靶控静脉麻醉的影响。方法：选择40例妇科腹腔镜检查术的病人，分为地中海贫血组（T组）和对照组（C组）各20例。观察瑞芬太尼复合异丙酚给药后意识消失时间、血液动力学变化以及麻醉诱导的平稳性，术中麻醉维持的方便性；记录术毕停药后有关指标。结果：T组意识消失时间明显短于C组，麻醉诱导期间2组均能引起明显的低血压，T组低血压发生率高于C组，但均未见严重的心血管副作用。2组术中血液动力学保持较低水平，麻醉维持简便易行；术后自主呼吸恢复时间、睁眼时间和拔除气管导管时间2组无统计学差异，术后疼痛评分和瑞芬太尼总用量差异亦无显著性。结论：瑞芬太尼复合异丙酚靶控静脉麻醉可安全地用于地中海贫血患者。 |
| 英文摘要: |
| objective：This study was designed to observe and compare the effects of Thalassanenia on anesthesia with target-controlled infusion of propofol-remifentani.Methods：40 ASAⅠandⅡwomen patients were divided into two groups: group T 20 patients with Thalassanenia and group C 20 patients without Thalassanenia. Anesthesia was induced with propofol and remifentanil given by TCL using two Graseby 3500 infusion pumps.Propofol-remifentanil target concentrations were titrated against the response of the patients during the maintenance of anesthesia. The changes in MAP and HR during induction , tracheal intubation , operation and the total amount of proofol and remifentanil consumed were recorded . At the end of operation, quality of anesthesia was evaluated. Post anesthetic recovery time and postoperative pain score(VAS score) were also assessed. Results：During induction MAP was significantly lower in two groups, and more patients developed hypotension in group T. the incidence of intubation response was lower in group T, but no serious cardiac adverse effects were observed. TLOC was significantly shorter in group T than group C. The duration from termination of anesthetics to full recovery of spontaneous breathing, eye opening at request and tracheal extubation, the total amount of remifentanil consumed and VAS score were similar among the two groups. Conclusion：Anesthesia with propofol-remifentanil by TCI is safe and effective in patients with Thalassanenia. |
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