| 楼英彪 应延风.缓释茶碱对中重度COPD患者生存质量的影响[J].实用中西医结合临床,2005,(1):8-9 |
| 缓释茶碱对中重度COPD患者生存质量的影响 |
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| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 生存质量 肺功能 茶碱 |
| 英文关键词: COPD QOL Lung function Theophylline |
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| 中文摘要: |
| 目的：用茶碱缓释片长期治疗中重度慢性阻塞性肺疾病（COPD）病人时肺功能、生存质量(QOL)和病情严重度的研究。方法：70例病人按是否连续服茶碱缓释片随机分为2组，30例治疗组病人中28例完成治疗，40例对照组病人中37例完成。结果：治疗1年后治疗组肺功能指标均高于治前，而对照组比治前下降，2组治疗前后无显著差异。治后2组肺功能指标FVC、FEV1有显著差异（P<0.01），治疗组肺功能显著高于对照组；QOL总均分、日常生活能力、社会活动、抑郁症状和焦虑症状在治疗组中治疗后显著降低（P<0.01），在对照组中尚有上升趋势，但与治前无显著差异。在1年随访期间病人发作次数（人次/年）显著低于对照组，治疗后首次发作时间和首次住院时间也明显长于对照组（P<0.01）。住院天数2组并无显著差异。结论：茶碱缓释片长期口服能显著改善病人的QOL，能改善和延缓肺功能下降速度，改善病情的严重度，QOL的改善和肺功能之间并无一致关系。 |
| 英文摘要: |
| Objective：To study the effects of theophylline sustained-release tablets in lung function ,QOL and severity to treat COPD. Methods：random case-control study,treatment group with theophylline sustained-release tablets 28 cases, matched group 37 cases16. Result：After one year , lung function were higher than control group that were lower than before treatment , FVC、FEV1，there were a significant difference（P<0.01），QOL：TMS，daily life ability, social activities ，depression anxiety state were lower in treatment group（P<0.01）.In one year follow-up period, fit numbers were lower than matched group，the first time fit and in hospital after treatment were more length（P<0.01）. Conclusion：theophylline sustained-release tablets played a key role in the amelioration of severity , QOL and lung function , there were not a good relation between QOL and lung function . |
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