楼英彪 应延风.缓释茶碱对中重度COPD患者生存质量的影响[J].实用中西医结合临床,2005,(1):8-9 |
缓释茶碱对中重度COPD患者生存质量的影响 |
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DOI: |
中文关键词: 慢性阻塞性肺疾病 生存质量 肺功能 茶碱 |
英文关键词: COPD QOL Lung function Theophylline |
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中文摘要: |
目的:用茶碱缓释片长期治疗中重度慢性阻塞性肺疾病(COPD)病人时肺功能、生存质量(QOL)和病情严重度的研究。方法:70例病人按是否连续服茶碱缓释片随机分为2组,30例治疗组病人中28例完成治疗,40例对照组病人中37例完成。结果:治疗1年后治疗组肺功能指标均高于治前,而对照组比治前下降,2组治疗前后无显著差异。治后2组肺功能指标FVC、FEV1有显著差异(P<0.01),治疗组肺功能显著高于对照组;QOL总均分、日常生活能力、社会活动、抑郁症状和焦虑症状在治疗组中治疗后显著降低(P<0.01),在对照组中尚有上升趋势,但与治前无显著差异。在1年随访期间病人发作次数(人次/年)显著低于对照组,治疗后首次发作时间和首次住院时间也明显长于对照组(P<0.01)。住院天数2组并无显著差异。结论:茶碱缓释片长期口服能显著改善病人的QOL,能改善和延缓肺功能下降速度,改善病情的严重度,QOL的改善和肺功能之间并无一致关系。 |
英文摘要: |
Objective:To study the effects of theophylline sustained-release tablets in lung function ,QOL and severity to treat COPD. Methods:random case-control study,treatment group with theophylline sustained-release tablets 28 cases, matched group 37 cases16. Result:After one year , lung function were higher than control group that were lower than before treatment , FVC、FEV1,there were a significant difference(P<0.01),QOL:TMS,daily life ability, social activities ,depression anxiety state were lower in treatment group(P<0.01).In one year follow-up period, fit numbers were lower than matched group,the first time fit and in hospital after treatment were more length(P<0.01). Conclusion:theophylline sustained-release tablets played a key role in the amelioration of severity , QOL and lung function , there were not a good relation between QOL and lung function . |
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