祝仲珍 王占科 熊小平 杨莉萍 陈致怀 王志.严重创伤MODS高血糖患者内毒素、胰岛素抵抗和胰岛素分泌指数变化[J].实用中西医结合临床,2005,(1):4-5 |
严重创伤MODS高血糖患者内毒素、胰岛素抵抗和胰岛素分泌指数变化 |
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DOI: |
中文关键词: 创伤 MODS 内毒素 胰岛素抵抗 胰岛素分泌 空腹高血糖 |
英文关键词: Traum, MODS, Endotoxin, Insulin resistance, Insulin secretion, Fasting glucose |
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中文摘要: |
目的:探讨严重创伤多脏器功能衰竭(MODS)高血糖患者血内毒素、胰岛素抵抗和胰岛素分泌功能变化及其临床价值。方法:观察创伤MODS高血糖和正常血糖组死亡率变化,测定创伤MODS高血糖和正常血糖组血内毒素、空腹血糖、空腹胰岛素等含量,计算稳态模式评估法胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-β)。结果:创伤MODS高血糖组病死率明显高于创伤MODS正常血糖组(P<0.01);创伤MODS高血糖组血内毒素含量、HOMA-β指数明显高于创伤MODS正常血糖组,创伤MODS高血糖组HOMA-β指数明显低于创伤MODS正常血糖组。结论:创伤MODS合并高血糖患者预后不良,内毒素在创伤MODS患者高血糖症中,发挥重要作用。 |
英文摘要: |
Objective: To study the signification of the The changes of the levels of the blood endotoxin, insulin resistance and insulin secretion in trauma MODS patients with high blood glucose.Methods: The death rates of all the groups are observed. The blood endotoxin, fasting glucose , insulin in all the groups are determined, and the indexes of HOMA-IR and HOMA-βare calculated.Results: The death rates of the trauma MODS patients with high blood glucose is higher than that with normal blood glucose.The levels of blood endotoxin and HOMA-IR in trauma MODS patients with high blood glucose are higher than that with normal blood glucose; The levels of the HOMA-βin trauma MODS patients with high blood glucose are higher than that with normal blood glucose. Conclusion:The trauma MODS patients with high blood glucose represents a bad prognosis, the blood endotoxin plays a important roles on the glycemia symptom in the trauma MODS patients. |
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