| 祝仲珍 王占科 熊小平 杨莉萍 陈致怀 王志.严重创伤MODS高血糖患者内毒素、胰岛素抵抗和胰岛素分泌指数变化[J].实用中西医结合临床,2005,(1):4-5 |
| 严重创伤MODS高血糖患者内毒素、胰岛素抵抗和胰岛素分泌指数变化 |
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| 中文关键词: 创伤 MODS 内毒素 胰岛素抵抗 胰岛素分泌 空腹高血糖 |
| 英文关键词: Traum, MODS, Endotoxin, Insulin resistance, Insulin secretion, Fasting glucose |
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| 中文摘要: |
| 目的：探讨严重创伤多脏器功能衰竭（MODS）高血糖患者血内毒素、胰岛素抵抗和胰岛素分泌功能变化及其临床价值。方法：观察创伤MODS高血糖和正常血糖组死亡率变化，测定创伤MODS高血糖和正常血糖组血内毒素、空腹血糖、空腹胰岛素等含量，计算稳态模式评估法胰岛素抵抗指数（HOMA-IR）和胰岛素分泌指数（HOMA-β）。结果：创伤MODS高血糖组病死率明显高于创伤MODS正常血糖组（P＜0.01）；创伤MODS高血糖组血内毒素含量、HOMA-β指数明显高于创伤MODS正常血糖组，创伤MODS高血糖组HOMA-β指数明显低于创伤MODS正常血糖组。结论：创伤MODS合并高血糖患者预后不良，内毒素在创伤MODS患者高血糖症中，发挥重要作用。 |
| 英文摘要: |
| Objective: To study the signification of the The changes of the levels of the blood endotoxin, insulin resistance and insulin secretion in trauma MODS patients with high blood glucose.Methods: The death rates of all the groups are observed. The blood endotoxin, fasting glucose , insulin in all the groups are determined, and the indexes of HOMA-IR and HOMA-βare calculated.Results: The death rates of the trauma MODS patients with high blood glucose is higher than that with normal blood glucose.The levels of blood endotoxin and HOMA-IR in trauma MODS patients with high blood glucose are higher than that with normal blood glucose; The levels of the HOMA-βin trauma MODS patients with high blood glucose are higher than that with normal blood glucose. Conclusion:The trauma MODS patients with high blood glucose represents a bad prognosis, the blood endotoxin plays a important roles on the glycemia symptom in the trauma MODS patients. |
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