| 钟瑜 常克 杨岑 杨国汉.鱼腥草注射液对膜性肾病大鼠的初步实验研究[J].实用中西医结合临床,2005,(1):1-2，32 |
| 鱼腥草注射液对膜性肾病大鼠的初步实验研究 |
|
| |
| DOI： |
| 中文关键词: 膜性肾病 鱼腥草注射液 实验研究 尿蛋白定量 光镜 免疫组化染色 |
| 英文关键词: houttuynia membranous nephritis Experiment study urinary protein content immunohistochemistry staining |
| 基金项目: |
|
| 摘要点击次数: 551 |
| 全文下载次数: 284 |
| 中文摘要: |
| 目的：探讨鱼腥草注射液对膜性肾病大鼠的影响及作用机制。方法：将造模大鼠分为4组：即模型对照组、鱼腥草注射液20mL/Kg组、鱼腥草注射液10mL/Kg组、地塞米松磷酸钠注射液0.1mg/Kg组，连同原有正常对照组，共5个组。实验结束时测定24h尿蛋白定量，并作光镜下观察及免疫组化染色。结果：鱼腥草注射液大、小剂量组24h尿蛋白定量较模型对照组显著减少（P< 0.05）；光镜下鱼腥草大剂量组较模型组肾小球周围炎性反应明显减轻，血管内仅有少量红细胞，体视学统计鱼腥草大小剂量组分叶肾小球较模型组有显著性减少（P<0.05），TGF-β１免疫组化染色结果鱼腥草大剂量组肾小球及周围组织着色明显较浅，免疫反应明显减轻。结论：鱼腥草注射液能降低造模大鼠的24h尿蛋白定量，对造模大鼠有减轻其病理损伤的作用。 |
| 英文摘要: |
| Objective:The study was designed to observe the effect of herba houttuyniae on SD MN rats and discuss it's mechanism of action. Methods: SD rats were made to membranous nephritis model by cation bovine serum albumin and divided into 4 groups, the model group, the high-dose and low-dose houttuynia group, Dex group. Heathy rats were used as normal contral group. Twenty-four hours' urinary protein content and plasma albumin, blood lipid were tested by the end of experiment. Pathological changes were observed by using light and used immunohistochemistry staining test. Resutts: As compared to model group, high-dose and low-dose houttuynia group rats showed less urinary protein excretion(P<0.05), Light 、 immunohistochemistry staining all showed that the pathologic changes in the high-dose and low-dose houttuynia group were lesser than that of the model group. Especially the high-dose houttuynia group. Conclusion: Houttuyniae can reduce urinary protein content.Houttuyniae also can reduce the pathologic changes of SD rats were made to membranous nephritis model by cation bovine serum albumin. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
