| 黄烈虎 叶荣 林晰敏.葛根素对糖尿病伴血管病变患者血浆内皮素、一氧化氮含量的影响[J].实用中西医结合临床,2004,(2):1-2 |
| 葛根素对糖尿病伴血管病变患者血浆内皮素、一氧化氮含量的影响 |
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| DOI： |
| 中文关键词: 葛根素 糖尿病 血管病变 内皮素 一氧化氮 |
| 英文关键词: Puerarin diabetes mellitus endothelin nitric oxide |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨葛根素对糖尿病微血管病患者血浆内皮素、一氧化氮含量影响，为临床糖尿病的血管并发症防治寻找理想方法。 方法：46例糖尿病伴血管病变患者分为治疗组和对照组，2组基础治疗相同，包括使用口服降糖药或/和胰岛素。治疗组在此基础上加用葛根素0.4g加入生理盐水250mL中静滴，1d 1次， 15d为1个疗程，连用3个疗程。治疗前后分别测定血浆ET、NO水平。 结果：治疗后，葛根素组ET下降，NO升高显著(P<0.01)；与对照组相比，葛根素组治疗后ET、NO改变有显著性差异（P<0.01）。 结论：：葛根素具有显著调节糖尿病伴血管病变患者血浆ET、NO水平作用，对血管内皮有保护作用。 |
| 英文摘要: |
| Objective: To evaluate the effects of puerarin on plasma endothelin and nitric oxide in diabetic patients with microvascular complications. Methods: Base treatments of all 46 cases were same, but the treatment of puerarin group was set up as follows: 400mg puerarin in 250mL 5% GNS, ivgtt, qd, every 15 days was taken as treatment course. The plasma ET and NO was measured before and after the treatments.Result: After the treatments, ET in puerarin group was significantly lower and NO was markedly higher (P<0.01). Compared with control group, ET and NO after treatments in puerarin group changed markedly (P<0.01). Conclusion: Puerarin can decrease plasma ET or increase NO in diabetic patients with microvascular complications. |
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