| 张海波 蔡安和 周荣耀 张闽光 杨秋泓.夏枯草及抗炎1号注射液经肝动脉联合灌注
治疗大鼠晚期肝癌的实验研究[J].实用中西医结合临床,2003,(4):1-3 |
| 夏枯草及抗炎1号注射液经肝动脉联合灌注
治疗大鼠晚期肝癌的实验研究 |
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| 中文关键词: 夏枯草注射液 抗炎1号注射液 大鼠肝癌 肝动脉灌注 实验研究 |
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| 中文摘要: |
| 目的：观察夏枯草及抗炎1号注射液经肝动脉联合灌注对大鼠晚期肝癌的治疗作用。方法：建立30只二乙基亚硝胺（DEN）诱发大鼠晚期原发性肝癌模型，随机分为中药组、化疗组和盐水组，每组各 10只。经胃、十二指肠动脉至肝固有动脉分别灌注生理盐水 0.5mL、夏枯草注射液0.6g/kg +抗炎1号注射液0.45g/kg、顺铂（DDP）4mg/kg+羟基喜树碱（HCPT）1.5mg/kg+5-氟脲嘧啶（5-FU）34mg/kg。结果：与化疗组和盐水组比较，中药组大鼠的一般情况较好，肝重/体重低，病理性肝损害轻，生存率高（90%对60%，70%，P<0.05）。结论：经肝动脉联合灌注夏枯草及抗炎1号注射液较灌注化疗药物对诱发性大鼠晚期肝癌具有更好的作用。 |
| 英文摘要: |
| Objective: To observe the therapeutic efficacy of prunella vulgaris l and kangyan no.I infused via hepatic artery against advanced Primary Liver Cancer in rat . Methods: 30 rats with advanced Primary Liver Cancer induced by DEN were divided into 3 groups randomly. Each group has 10 rats and were infused with Normal Saline, Prunellae Vulgaris L and Kangyan No.I, and chemiotherapy( include DDP+HCPT+5-FU) from gastroduodenal artery into hepatic artery respectively. The survival rate、general state、liver weight /rat weight and the hepatic pathomorhiesm were compared among 3 groups. Result: Compared with other groups TCM group showed good result in the survival rate （90% aginst 60%；70% P<0.05）、general state 、pathologic Lesion of liver and liver weight /rat weight was lower than NS group significantly, but had no statistics difference from chemiotherapy group(P>0.05). Conclusion: The efficacy of prunellae vulgaris l and kangyan no.I infused via hepatic artery was better than other groups in treating rat advanced Primary Liver Cancer induced by DEN. |
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