妊娠期念珠菌性阴道炎的病原鉴定、药敏分析和治疗

苏秀馨; 褚瑞峰; 肖庆忠; 陈涛

文章摘要

苏秀馨褚瑞峰肖庆忠陈涛.妊娠期念珠菌性阴道炎的病原鉴定、药敏分析和治疗[J].实用中西医结合临床,2003,(3):3-4

妊娠期念珠菌性阴道炎的病原鉴定、药敏分析和治疗

DOI：

英文关键词: pregnancy monilial vaginitis identification of pathogey Drug susceptibility analysi Drug resistance Drug therapy

基金项目:广州市科技局重大攻关资助项目（编号2000-Z-027-01-2）

作者	单位
苏秀馨褚瑞峰肖庆忠陈涛	广东省广州市海珠区妇幼保健院；广州医学院第一附属医院检验科

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中文摘要:

目的：探讨妊娠期念珠菌性阴道炎的病原体分布、体外药敏结果和初步临床治疗效果。方法：对160株孕妇感染标本中分离出的念珠菌进行鉴定，进行药敏分析；对其中可随访的60例患者进行阴道置入制霉菌素制剂治疗。结果：白色念珠菌的检出率最高（60.6%）；体外药敏分析显示：对各种念珠菌的总体敏感率大于90%的抗真菌药物有制霉菌素（94.4%）、伊曲康唑（93.8%）、两性霉素B （93.8%）、5-氟胞嘧啶（91.9）。制霉菌素制剂的治疗总有效率93.3%，与体外药敏结果（94.4%）基本一致。结论：妊娠期念珠菌性阴道炎以白色念珠菌感染为主，临床治疗可首选制霉菌素，可考虑选用两性霉素B、伊曲康唑、5-氟胞嘧啶等药物。

英文摘要:

Objective： To discuss the distributions and drug sensitivity of pathogeny, and clinical therapeutic efficacy of the pregnant monilial vaginitis. Methods： To identify the 160 monilia from 160 patients ,and the bacteria's drug susceptibility test were preformed.Among them,60 patients were treated with nystatin.Results：Total of 160 strains pathogens were isolated from 160 pregnant women from January to September in 2002,among them 97strains were Candida albicans (97/160,60.6%). The total percentage of susceptibility of Monilia to 5-fluorocytosine, amphotericin B , nystatin and itraconazole were 91.9% ,93.8% , 94.4% and 93.8%, respectively . The total therapeutic efficacy of nystatin for the pregnant monilial vaginitis was 93.3%. Conclusions： The major pathogeny of the pregnant monilial vaginitis was Candida albicans,the first choice antibiotics for clinical therapy was nystatin,5-fluorocytosine, amphotericin Band itraconazole also can be used.

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