| 胡燕珍，刘建坤，黄斌，陈乐.基于外翻肠囊法研究乌蕨醇提物的肠吸收特性[J].实用中西医结合临床,2022,22(5):121-124 |
| 基于外翻肠囊法研究乌蕨醇提物的肠吸收特性 |
| Study on Intestinal Absorption Characteristics of Alcohol Extract of Odontosoria Chinensis Based on Everted Intestinal Sac Method* |
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| DOI： |
| 中文关键词: 乌蕨 外翻肠囊法 原儿茶酸 原儿茶醛 牡荆苷 |
| 英文关键词: Odontosoria chinensis Everted intestinal sac method Protocatechuic acid Protocatechuic aldehyde Vitexin |
| 基金项目:江西省中医药管理局科技计划项目（No.2019A318）；江西省中医药中青年骨干人才（第一批）培养计划项目（编号：赣中医药科教字[2020]2号） |
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| 中文摘要: |
| 目的：研究乌蕨醇提物在肠道中的吸收特性。方法：采用大鼠外翻肠囊实验模型，收集高、中、低质量浓度乌蕨醇取物给药后不同时间点的肠囊吸收液；采用高效液相色谱法检测肠囊吸收液样品中原儿茶酸、原儿茶醛、牡荆苷3种化学成分含量，计算吸收动力学参数（Q、Ka），考察各成分肠吸收特征。结果：原儿茶酸、原儿茶醛、牡荆苷3种成分在乌蕨醇提物中能被检测出，但在其肠吸收液中未被检测到。结论：在本研究实验条件下，肠道对乌蕨中原儿茶酸、原儿茶醛、牡荆苷3种指标性成分未有吸收，具体原因还有待进一步实验探究。 |
| 英文摘要: |
| Objective: To study the absorption characteristics of alcohol extract of Odontosoria chinensis in intestine. Methods: The experimental model of everted intestinal sac in rats was used to collect the intestinal sac absorption solution at different time points after administration of high, medium and low mass concentrations of alchol extract of Odontosoria chinensis; the contents of protocatechuic acid, protocatechuic aldehyde and vitexin in intestinal sac absorptionsolution samples were detected by HPLC. The absorption kinetic parameters (Q, KA) were calculated to investigate the intestinal absorption characteristics of each components. Results: Protocatechuic acid, protocatechuic aldehyde and vitexin could be detected in the alcohol extract of Odontosoria chinensis, but not in its intestinal sac absorption solution. Conclusion: Under the experimental conditions of this study, the intestinal tract don't absorb protocatechuic acid, protocatechuic aldehyde and vitexin, and the specific reasons need to be further explored. |
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