| 南黎.纤维蛋白原与白蛋白比值对慢阻肺患者急性加重风险的预测价值分析[J].实用中西医结合临床,2022,22(11): |
| 纤维蛋白原与白蛋白比值对慢阻肺患者急性加重风险的预测价值分析 |
| Predictive value of fibrinogen to albumin ratio for acute exacerbation risk in patients with chronic obstructive pulmonary disease |
| 投稿时间：2022-04-22 修订日期：2022-05-11 |
| DOI： |
| 中文关键词: 纤维蛋白原与白蛋白比值 慢性阻塞性肺病 急性加重 预测价值 |
| 英文关键词: fibrinogen to albumin ratio chronic obstructive pulmonary disease exacerbations predictive value |
| 基金项目: |
|
| 摘要点击次数: 312 |
| 全文下载次数: 92 |
| 中文摘要: |
| 目的 分析纤维蛋白原与白蛋白比值（FAR）对慢性阻塞性肺疾病（COPD）患者急性加重风险的预测价值。方法 选取2019年11月至2021年11月在我院接受治疗的86例COPD患者作为COPD组，同时选取同期来我院健康体检的40例健康人群作为对照组。根据患者入院前1年急性加重次数将COPD患者分为急性加重风险组（n=36）和无急性加重风险组（n=50）。所有纳入对象入院后均检测血清纤维蛋白原（FIB）、白蛋白（ALB）水平，并计算FAR比值。分析比较各组基本资料、生化指标，采用受试者工作特性曲线（ROC）评估血清FAR比值对COPD患者急性加重风险的预测价值，同时采用多因素Logistic回归分析影响COPD患者急性加重风险的相关因素。结果 COPD组血清FIB、FAR水平均明显高于对照组（P<0.05），ALB水平明显低于对照组（P<0.05）。急性加重风险组患者血清FIB、FAR水平明显高于无急性加重风险组（P<0.05），ALB水平明显低于无急性加重风险组（P<0.05）。ROC曲线结果显示，FAR预测COPD患者急性加重风险的曲线下面积为0.806，截断值0.29，敏感度、特异度分别为89.7%、85.3%，FIB曲线下面积为0.658，截断值8.50g/L，敏感度、特异度分别为75.6%、69.9%，ALB曲线下面积为0.689，截断值30.62g/L，敏感度、特异度分别为78.4%、70.2%。多因素logistic回归模型分析结果显示，血清FIB[OR（95%CI）：3.39（1.73~6.42）]、ALB[OR（95%CI）：3.56（1.79~7.06）]、FAR[OR（95%CI）：4.04（1.70~9.59）]均为影响COPD患者出现急性加重风险的相关因素（P<0.05）。结论 FAR比值在COPD患者急性加重风险中升高，是增加COPD患者急性加重风险的相关因素之一，有望作为预测患者出现急性加重风险的有效指标。 |
| 英文摘要: |
| Objective: To analyze the predictive value of the fibrinogen to albumin ratio (FAR) for the risk of acute exacerbations in patients with chronic obstructive pulmonary disease (COPD). Methods: A total of 86 COPD patients who were treated in our hospital from November 2019 to November 2021 were selected as the COPD group, and 40 healthy people who came to our hospital for physical examination during the same period were selected as the control group. COPD patients were divided into acute exacerbation risk group (n=36) and no exacerbation risk group (n=50) according to the number of exacerbations in the 1 year before admission. Serum fibrinogen (FIB) and albumin (ALB) levels after admission in all the included subjects were detected, and the FAR ratio was calculated. The basic data and biochemical indexes of each group were analyzed and compared, and the receiver operating characteristic curve (ROC) was used to evaluate the predictive value of serum FAR ratio on the risk of acute exacerbation in patients with COPD. At the same time, multivariate Logistic regression was used to analyze the related factors affecting the risk of acute exacerbation in patients with COPD. Results: The serum levels of FIB and FAR in the COPD group were higher than those in the control group(P<0.05), and the ALB level was lower than that in the control group(P<0.05). The serum FIB and FAR levels in the acute exacerbation risk group were higher than those in the non-acute exacerbation risk group(P<0.05), and the ALB level was lower than that in the non-acute exacerbation risk group(P<0.05). The results of the ROC curve showed that the area under the curve of FAR for predicting the risk of acute exacerbation in COPD patients was 0.806, the cut-off value 0.29, the sensitivity and specificity were 89.7% and 85.3%, respectively, and the area under the FIB curve was 0.658, and the cut-off value was 8.50g/L, and the sensitivity and specificity were 75.6% and 69.9%, respectively, and the area under the ALB curve was 0.689, and the cut-off value was 30.62 g/L. The sensitivity and specificity were 78.4% and 70.2%, respectively. The results of multivariate logistic regression model analysis showed that serum FIB [OR(95%CI): 3.39(1.73-6.42)], ALB [OR(95%CI): 3.56(1.79-7.06)], FAR[OR(95%CI): 4.04(1.70-9.59)] were all related factors affecting the risk of acute exacerbation in COPD patients(P<0.05). Conclusion: FAR ratio increases in the risk of acute exacerbation in patients with COPD. It is one of the relevant factors to increase the risk of acute exacerbation in patients with COPD. It is expected to be an effective index to predict the risk of acute exacerbation. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
