| 张婷,陈俊,曾建伟,戴雨婷,吴广文.基于数据挖掘与网络药理学分析陈可冀主编之清宫系列书籍治疗骨关节炎外用方的用药规律[J].实用中西医结合临床,2022,22(4): |
| 基于数据挖掘与网络药理学分析陈可冀主编之清宫系列书籍治疗骨关节炎外用方的用药规律 |
| Based on data mining and network pharmacology analyse the using drugs regularity of external prescription for osteoarthritis in Royal Formulary of Qing Dynasty edited by Chen Keji |
| 投稿时间：2022-02-04 修订日期：2022-03-03 |
| DOI： |
| 中文关键词: 数据挖掘；清宫书籍；组方用药规律 骨关节炎；网络药理学 |
| 英文关键词: data mining Royal Formulary of Qing Dynasty books ?using drugs component and regularity Osteoarthritis network pharmacology |
| 基金项目:福建中医药大学校管课题（X2021006-重点） |
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| 中文摘要: |
| 目的 借用数据挖掘软件与网络药理学分析陈可冀院士主编的清宫系列书籍中治疗骨关节炎外用方的用药规律。方法 从清宫系列书籍中筛选出治疗骨关节炎的外用方剂，利用Excel软件建立数据库，基于中医传承辅助平台（V3.0）统计中药及其性味、归经、功效的使用频次情况及关联规则和聚类分析的结果。在此基础上结合专业知识组出新方（荣筋祛痹方），再用网络药理学验证荣筋祛痹方治疗骨关节炎的可行性。结果 从清宫系列书籍中筛选出治疗骨关节炎的外用方剂103首，频数统计显示常见外用药物以乳香、当归、没药、防风等为主，多用性温、平，味辛、苦，入肝、脾经的中药，基于此分析中药的关联规则聚类出核心组合。综合上述结果组出新方（荣筋祛痹方）结论 清宫系列书籍治疗骨关节炎的外用药主要以活血化瘀、祛风除湿为主，兼以补益肝肾。用药规律符合骨关节炎外因感受风寒湿邪、内因肝肾亏虚从而产生中间病理产物-瘀血的中医发病特点。由此分析聚类出的中药核心组合对骨关节炎的治疗用药具有参考价值，在此基础上用网络药理学验证过的新方（荣筋祛痹方）对骨关节炎是否有治疗价值提供了理论依据。 |
| 英文摘要: |
| Objective This study is analyzing the medication law of external prescriptions for the treatment of osteoarthritis in Royal Formulary of Qing Dynasty books edited by academician Chen Keji by using data mining software and network pharmacology. Methods We selected the external prescriptions for the treatment of osteoarthritis from the books,and use Excel software to build database ,based on the TCM inheritance assistance platform (V3.0), the usage frequency, association rules and cluster analysis results of traditional Chinese medicine and its taste, channel?tropism and efficacy . On this basis, combined with professional knowledge, a new formula (Rongjin Qubi Fang) is formed, and the feasibility of Rongjin Qubi Fang in the treatment of osteoarthritis is proved by the network pharmacology.Based on 103 external prescriptions for the treatment of osteoarthritis were selected from the books and the frequency statistics showed that the common topical drugs were mainly frankincense, Angelica sinensis, myrrh and Fangfeng whose the tropism?of?taste are warm, flat, spicy, bitter, into the liver, spleen.Based on this analysis, the core combinations were clustered according to the association rules of TCM has reference value for the treatment of osteoarthritis.On this basis, it provides theoretical evidence whether the new formula (Rongjin Qubi Fang) verified by network pharmacology has therapeutic value for osteoarthritis.Result The external?prescription used in the treatment of osteoarthritis are mainly promoting blood circulation and removing stasis, dispelling wind and dehumidification, and tonifying liver and kidney. Using drugs regularity is consistent with the characteristics of the pathogenesis of osteoarthritis in TCM, which generate the intermediate pathological product of blood stasis due to the experience wind chill and dampness, liver and kidney deficiency due to internal causes.Based on this analysis, the core combination of TCM clustering has reference value for the treatment of osteoarthritis. On this basis, the new prescription (Rongjin Qubi Fang) verified by network pharmacology provide the theoretical basis for the treatment of osteoarthritis. |
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