P504s、CK-HMW、p63、S-100蛋白与前列腺癌病理分级的关系

段凯军; 李青

文章摘要

段凯军，李青.P504s、CK-HMW、p63、S-100蛋白与前列腺癌病理分级的关系[J].实用中西医结合临床,2021,21(4):12-14,49

P504s、CK-HMW、p63、S-100蛋白与前列腺癌病理分级的关系

Relationship Between P504s, CK-HMW, p63 Protein and S-100 Protein and Pathological Grades of Prostate Cancer

DOI：

中文关键词: 前列腺癌病理分级 ?琢-甲酰基辅酶A-消旋酶高分子量角蛋白 p63蛋白 S-100蛋白

英文关键词: Prostate cancer Pathological grades ?琢-formyl coenzyme A-racemase Human high molecular weight cytokeratin p63 protein S-100 protein

基金项目:

作者	单位
段凯军，李青	河南省商丘市第四人民医院病理科

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中文摘要:

目的：探讨前列腺癌病理分级与?琢-甲酰基辅酶A-消旋酶、人高分子量细胞角蛋白、p63蛋白及S-100蛋白的关系。方法：收集2017年1月~2020年10月前列腺穿刺活检标本，前列腺癌标本92例，纳入PCa组；良性前列腺增生标本80例，纳入BPH组。所有标本均行免疫组化检测?琢-甲酰基辅酶A-消旋酶和人高分子量细胞角蛋白、p63、S-100蛋白的表达，光镜下观察前列腺癌患者病理组织学形态，进行Gleason分级评分。比较?琢-甲酰基辅酶A-消旋酶、人高分子量细胞角蛋白、p63、S-100蛋白在PCa组、BPH组中的表达阳性率，以及在不同Gleason分级中的表达强度，采用Spearman相关性分析?琢-甲酰基辅酶A-消旋酶水平、人高分子量细胞角蛋白、p63、S-100蛋白表达强度与Gleason分级的相关性。结果：?琢-甲酰基辅酶A-消旋酶在PCa组中表达阳性率高于BPH组，人高分子量细胞角蛋白、p63、S-100蛋白在PCa组中表达阳性率低于BPH组（P均＜0.05）；PCa组中Gleason评分≤7分者?琢-甲酰基辅酶A-消旋酶表达强度低于Gleason评分＞7分者（P＜0.05），人高分子量细胞角蛋白、p63、S-100蛋白在PCa组不同Gleason分级中的表达强度差异无统计学意义（P＞0.05）。Spearman相关性分析结果显示，Gleason分级与?琢-甲酰基辅酶A-消旋酶表达强度呈正相关性（r=0.632，P＜0.05），与人高分子量细胞角蛋白（r=0.212，P＞0.05）、p63（r=0.197，P＞0.05）、S-100蛋白（r=0.244，P＞0.05）表达强度无显著相关性。结论：?琢-甲酰基辅酶A-消旋酶、人高分子量细胞角蛋白、p63、S-100蛋白在前列腺癌的鉴别诊断中有重要应用价值，?琢-甲酰基辅酶A-消旋酶可作为评价前列腺癌病情与预后的重要参考指标。

英文摘要:

Objective: To explore the relationship between pathological grades of prostate cancer and ?琢-formyl coenzyme A-racemase, Human high molecular weight cytokeratin, p63 protein and S-100 protein. Methods: From January 2017 to October 2020, 92 prostate cancer specimens were included in PCa group; 80 benign prostatic hyperplasia specimens were included in BPH group. The expressions of ?琢-formyl coenzyme A-racemase, Human high molecular weight cytokeratin, p63 protein, S-100 protein were detected by immunohistochemistry. The histopathological morphology of prostate cancer patients was observed under light microscope, and Gleason grading was performed. The levels of ?琢-formyl coenzyme A-racemase, the positive rates of Human high molecular weight cytokeratin, p63 protein and S-100 protein expression in PCa group and BPH group, and the expression intensity of these indicators in different Gleason grades were compared. The correlation between ?琢-formyl coenzyme A-racemase, Human high molecular weight cytokeratin, p63 protein, S-100 protein expression intensity and Gleason grades were analyzed by Spearman correlation analysis. Results: The positive rate of ?琢-formyl coenzyme A-racemase expression in PCa group was higher than that in BPH group, while the positive rates of Human high molecular weight cytokeratin, p63 protein and S-100 protein expression in PCa group were lower than those in BPH group (all P＜0.05). The expression intensity of ?琢-formyl coenzyme A-racemase of patients with Gleason score ≤7 points in PCa group was lower than that of patients with Gleason score＞7 points (all P＜0.05); but there was no significant difference in the expression intensity of Human high molecular weight cytokeratin, p63 and S-100 protein in different Gleason grades of PCa group (P＞0.05). Spearman correlation analysis showed that Gleason grade was positively correlated with ?琢-formyl coenzyme A-racemase expression intensity(r=0.632, P＜0.05), but not with Human high molecular weight cytokeratin (r=0.212, P＞0.05), p63 (r=0.197, P＞0.05) and S-100 protein (r=0.244, P＞0.05). Conclusion: ?琢-formyl coenzyme A-racemase, Human high molecular weight cytokeratin, p63 protein and S-100 protein have important application value in the differential diagnosis of prostate, ?琢-formyl coenzyme A-racemase can be used as an important reference index for evaluating the disease condition and prognosis of prostate cancer.

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