| 陈莉莉 崔英 陈晓勇 陈瑾 祝佩.环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产可行性分析[J].实用中西医结合临床,2021,21(3):4-7 |
| 环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产可行性分析 |
| Feasibility Analysis of Cyclosporine with Combined Low-molecular Weight Heparin Calcium and "Jiajian Shoutai Pilula"in the Treatment of Unexplained Recurrent Spontaneous Abortion |
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| DOI： |
| 中文关键词: 原因不明复发性流产 环孢素 低分子肝素钙 寿胎丸 |
| 英文关键词: Unexplained%recurrent%spontaneous%aboaion %Cyclosporine %Low-molecular%weight%heparin%calcium %Shoutai%pilula |
| 基金项目:江西省卫生和计生委员会中医药科研基金项目（编号：2017A104） |
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| 中文摘要: |
| 目的：观察环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产的临床疗效。方法：将 2017 年 2 月 ~2019 年
7 月收治的 60 例原因不明复发性流产患者分为治疗组、对照组各 30 例，治疗组采用环孢素联合低分子量肝素钙及寿胎丸加减治疗，对
照组采用低分子量肝素钙联合寿胎丸加减治疗，两组疗程均为发现怀孕起至孕 12 周。 观察比较两组临床疗效，治疗前后临床症状
积分、 CD4 + /CD8 + 值，人绒毛膜促性腺激素水平和妊娠结局。 结果：治疗组总有效率为 90.00% ，高于对照组的 70.00% ，差异有统计
学意义， P ＜0.05 ；治疗后，治疗组与对照组中医临床症状总积分值与治疗前相比较，均有明显下降，治疗组总积分值低于对照组，两
组比较有显著性差异， P ＜0.05 ；两组 CD4 + /CD8 + 值、人绒毛膜促性腺激素水平、妊娠成功率治疗后较治疗前均有改善，且治疗组改
善程度优于对照组，两组比较有显著性差异， P ＜0.05 。结论：环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产有
较好的临床疗效。 |
| 英文摘要: |
| Objective:%To%observe%the%clinical%efficacy%of%cyclosporine%combined%with%low-molecular%weight%heparin%calcium%and%
"Jiajian%Shoutai%pilula"%in%the%treatment%of%unexplained%recurrent%spontaneous%abortion.%Methods:%From%February%2017%to%July%2019,%60%
admitted%patients%with%unexplained%recurrent%spontaneous%abortion%were%divided%into%the%treatment%group%and%the%control%group,%with%30%
cases%in%each%group.%The%treatment%group%was%treated%with%cyclosporine%combined%with%low-molecular%weight%heparin%calcium%and%"Jiajian%
Shoutai%pilula",%while%the%control%group%was%treated%with%low-molecular%weight%heparin%calcium%combined%with%"Jiajian%Shoutai%pilula".%
The%course%of%treatment%in%both%groups%were%from%the%discovery%of%pregnancy%to%the%12th%week%of%pregnancy.%Observed%and%compared%the%
clinical%efficacy,%clinical%symptom%scores%before%and%after%treatment,%chorionic%gonadotropin%level%and%pregnancy%outcome%of%the%two%
groups.%Results:%The%total%effective%rate%of%the%treatment%group%was%90.00%,%higher%than%70.00%%of%the%control%group,%the%difference%was%
statistically%significant,% P ＜0.05;%after%treatment,%the%total%scores%of%TCM%clinical%symptoms%in%the%treatment%group%and%the%control%group%
were%significantly%lower%than%those%before%treatment,%and%the%total%integral%value%of%the%treatment%group%was%lower%than%that%of%the%control%
group,%there%was%a%significant%difference%between%the%two%groups,% P ＜0.05;%the%immune%cells,%levels%and%pregnancy%success%rate%of%the%two%
groups%were%improved%after%treatment,%and%the%improvement%degree%of%the%treatment%group%was%better%than%that%of%the%control%group,%there%
was%a%significant%difference%between%the%two%groups,% P ＜0.05.%Conclusion:%Cyclosporine%combined%with%low-molecular%weight%heparin%
calcium%and%"Jiajian%Shoutai%pilula"%has%good%clinical%effect%in%the%treatment%of%unexplained%recurrent%spontaneous%abortion. |
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