| 王小辉,葛来安,蓝阳,吴媛.黄芪汤加减联合穴位贴敷对慢传输型便秘患者胃肠激素的影响[J].实用中西医结合临床,2021,21(9): |
| 黄芪汤加减联合穴位贴敷对慢传输型便秘患者胃肠激素的影响 |
| Effect of modified Huangqi decoction combined with Acupoint Application on gastrointestinal hormones in patients with slow transit constipation |
| 投稿时间：2021-02-23 修订日期：2021-03-09 |
| DOI： |
| 中文关键词: 黄芪汤 穴位贴敷 慢传输型功能性便秘 胃肠激素 |
| 英文关键词: Huangqi Decoction acupoint application slow transit functional constipation gastrointestinal hormone |
| 基金项目:江西省中医药管理局科技计划项目(2018A144);国家自然科学基金项目(82060840) |
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| 中文摘要: |
| 目的：观察黄芪汤加减联合穴位贴敷治疗慢传输型功能性便秘(STC)患者的临床疗效及对胃肠激素( MTL、SP、VIP)的影响。方法：将符合纳入标准的120例患者随机分为2组,观察组60例,采用黄芪汤加减联合穴位贴敷治疗；对照组60例,采用口服乳果糖联合枸橼酸莫沙必利分散片治疗,均治疗4周为1疗程。记录症状积分,比较临床疗效,比较两组患者治疗前后血清 MTL、SP、VIP的变化。结果：观察组总有效率(95.00%)显著优于对照组(81.67%)(P<0.05)。两组患者粪便性状,腹胀,排便时间,下坠、不尽、胀感,排便费力,排便频率等症状均较前显著改善(P＜0.05),且观察组各症状的改善效果均优于对照组(P＜0.05)；治疗后两组患者血清MTL、SP水平均较治疗前升高,且观察组高于对照组(P<0.05),治疗后两组患者的血清VIP水平较治疗前均降低(P<0.05),并且观察组显著低于对照组(P<0.05)。结论：黄芪汤加减联合穴位贴敷治疗STC疗效显著,能改善各项临床症状,其作用可能与调节胃肠激素( MTL、SP、VIP)有关。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of modified Huangqi decoction combined with Acupoint Application in the treatment of slow transit functional constipation (STC) and its influence on gastrointestinal hormones (MTL, SP, VIP). Methods: 120 patients who met the inclusion criteria were randomly divided into two groups, the observation group (60 cases) was treated with Huangqi decoction combined with acupoint application; the control group (60 cases) was treated with oral lactulose combined with Mosapride Citrate Dispersible Tablets, with a course of 4 weeks. The symptom scores were recorded, the clinical efficacy was compared, and the changes of serum MTL, SP and VIP were compared between the two groups before and after treatment. Results: the total effective rate of the observation group (95.00%) was significantly better than that of the control group (81.67%) (P < 0.05). Two groups of patients with fecal properties, abdominal distension, defecation time, falling, not enough, distension, defecation, defecation frequency and other symptoms were significantly improved compared with the treatment (P < 0.05), and the improvement effect of each symptom in the observation group was better than that in the control group (P < 0.05); after treatment, the levels of serum MTL and SP in two groups were higher than those before treatment, and the observation group was higher than that in the control group (P < 0.05) The level of serum VIP in the observation group was significantly lower than that in the control group (P < 0.05). Conclusion: Huangqi decoction combined with acupoint application has a significant effect in the treatment of STC, which can improve the clinical symptoms, and its effect may be related to the regulation of gastrointestinal hormones (MTL, SP, VIP). |
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