| 张平,项凤梅,胡子毅,李人亮.四君子汤类方治疗消化性溃疡有效性Meta分析[J].实用中西医结合临床,2021,21(1):6-10,156 |
| 四君子汤类方治疗消化性溃疡有效性Meta分析 |
| The Effectiveness Meta-analysis of Sijunzi Decoction in the Treatment of Peptic Ulcer |
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| DOI： |
| 中文关键词: 消化性溃疡 四君子汤 香砂六君子汤 参苓白术散 系统评价 Meta分析 |
| 英文关键词: Peptic ulcer Sijunzi decoction Xiangshaliujunzi decoction Shenlingbaizhu powder Systematic review Meta-analysis |
| 基金项目:江西省中医药中青年骨干人才培养计划（编号：赣中医药科教字[2020]2号）； 江西省卫生计生委中医药科研课题（编号：2018A081） |
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| 中文摘要: |
| 目的：系统评价四君子汤类方治疗消化性溃疡的临床疗效。方法：计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库四大中文数据库四君子汤类方治疗消化性溃疡的所有随机对照试验，检索时限为建库至2020年3月。全面收集及追溯纳入研究的文献，根据纳入、排除标准筛选文献并提取相关数据，采用RevMan5.3软件对数据进行Meta分析。结果：共纳入22个随机对照试验，总计2 688例患者，涉及四君子汤、香砂六君子汤、参苓白术散3个方剂。Meta分析结果显示，在临床总有效率方面，单用中药治疗消化性溃疡组优于对照组（OR=3.04，95%CI 2.16~4.29，P＜0.000 01）；中西医结合治疗消化性溃疡组优于对照组（OR=3.68，95%CI 2.73~4.96，P＜0.000 01）。在幽门螺杆菌根除率方面，香砂六君子汤联合西药治疗组优于对照组OR= 4.59，95%CI 2.39~8.79，P＜0.000 01。在减少复发率方面，治疗组溃疡复发率低于对照组（治疗后6个月OR=0.24，95%CI 0.13~0.42，P＜0.000 01；治疗后1年OR=0.27，95%CI 0.16~0.45，P＜0.000 01）。不良反应发生率方面，治疗组不良反应事件发生率低于对照组（OR=0.32，95%CI 0.21~0.50，P＜0.000 01）。结论：与单纯西药治疗相比，四君子汤类方单用或联合西药辅助治疗消化性溃疡在临床疗效、预防溃疡复发、减少西药不良反应方面疗效可能更佳，但这仍需要更多的高质量研究加以证实。 |
| 英文摘要: |
| Objective: To systematically evaluate the clinical effect of Sijunzi decoction in the treatment of peptic ulcer. Methods: Four chinese databases (CNKI, Wanfang, VIP and CBM) were searched by computer for RCTs of Sijunzi decoction similar recipe in the treatment of peptic ulcer, from the establishment of the database to March 2020. According to the inclusion and exclusion criteria, the literatures were screened. And the relevant datas were extracted and given methodlogical quality evaluation. The datas were given a Meta-analysis by using RevMan 5.3 software. Result: Totally 22 RCTs involving 2 688 patients were included in the study, and involving three prescriptions of Sijunzi decoction, Xiangshaliujunzi decoction and Shenlingbaizhu powder. The results of meta-analysis showed: in clinical total effective rate, the traditional chinese medicine group was superior to the control group (OR=3.04, 95%CI: 2.16~4.29, P＜0.000 01); the integrated chinese and western medicine group was superior to the control group (OR=3.68, 95%CI: 2.73~4.96, P＜0.000 01). In Hp eradication rate, the Xiangshaliujunzi decoction combined with western medicine treatment group was better than the control group (OR=4.59, 95%CI: 2.39~8.79, P＜0.000 01). In reducing the recurrence rate, the recurrence rate of ulcer in the treatment group was lower than that in the control group (OR=0.24, 95%CI: 0.13~0.42, P＜0.000 01, 6 months after treatment; and OR=0.27, 95%CI: 0.16~0.45, P＜0.000 01, 1 year after treatment). The incidence of adverse events in the treatment group was lower than that in the control group (OR= 0.32, 95%CI: 0.21~0.50, P＜0.000 01). Conclusion: Compared with western medicine alone, Sijunzi decoction similar recipe alone or combined with western medicine may be more effective in the treatment of peptic ulcer in clinical efficacy, prevention of ulcer recurrence and reduction of adverse reactions of western medicine, but it still needs more high-quality research to confirm. |
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