| 唐晓玲,余涛,熊林楷,梁启军,余炅,王珠,熊墨年.益气清毒法对肺癌患者舌脉象动态演变干预的客观化研究[J].实用中西医结合临床,2021,21(9): |
| 益气清毒法对肺癌患者舌脉象动态演变干预的客观化研究 |
| Objective study on effect of Yiqi Qingdu therapy to dynamic evolution of tongue and pulse in patients with lung cancer |
| 投稿时间：2020-12-25 修订日期：2021-02-25 |
| DOI： |
| 中文关键词: 益气清毒法 肺癌 舌象 脉象 中医客观化研究 |
| 英文关键词: Yiqiqingdu Lung cancer Tongue picture Pulse condition TCM objective study |
| 基金项目:江西省卫生计划生育委员会中医药科研(NO.2015A082)；国家中医药管理局第一批重点研究室—恶性肿瘤益气清毒重点研究室项目(NO.国中医药函[2009]95号)；国家中医药管理局—熊墨年全国名老中医药专家传承工作室项目(NO.国中医药人教发[2013]47号) |
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| 中文摘要: |
| 目的：分析中晚期肺癌患者在中医益气清毒法干预后舌脉象客观化参数的动态演变，为中医临床客观化诊疗提供参考。方法：将100例中晚期肺癌患者随机分为治疗组50例和对照组50例，治疗组给予中医益气清毒综合治疗，对照组给予西医治疗，两组均治疗4个疗程，分别在治疗前、治疗2个疗程结束后及治疗4个疗程结束后各采集1次舌脉象参数，观察治疗过程中舌象和脉象参数的变化。结果：(1)舌象变化：治疗组:与治疗前相比，治疗2个疗程患者的润燥指数、厚薄指数、腐腻指数均有明显变化（p<0.05）；治疗4个疗程与治疗前相比，患者的润燥指数、裂纹指数、厚薄指数、腐腻指数具有明显变化（P<0.05）；治疗4个疗程与治疗2个疗程相比，裂纹指数和厚薄指数则有明显差异（P<0.05）。对照组:与治疗前相比，相比，治疗2个疗程和治疗4个疗程患者的润燥指数、裂纹指数、腐腻指数指数均有明显变化（P<0.05）；治疗4个疗程与治疗2个疗程相比，润燥指数下降和裂纹指数升高，均有显著意义（P<0.05）。两组间对比：治疗2个疗程及治疗4个疗程后的两组比较，润燥指数、厚薄指数、腐腻指数、裂纹指数均有明显差异（P<0.05）。(2)脉象变化：治疗组：与治疗前相比，治疗2个疗程及治疗4个疗程的患者h1、U、P明显升高，h3/h1明显降低，差异有统计学意义（P<0.05）；治疗4个疗程与治疗2个疗程比较，h1、U、 h3/h1变化有明显差异（P<0.05）。对照组：与治疗前相比，治疗2个疗程的患者h3/h1明显降低，差异有统计学意义（P<0.05）；治疗4个疗程与治疗前相比，h1、U、P明显升高，h3/h1明显降低，差异有统计学意义（P<0.05）；治疗4个疗程与治疗2个疗程相比，U升高，存在明显差异（P<0.05）。两组间对比：治疗2个疗程U值有显著差异（P<0.05），治疗组比对照组升高更明显；治疗4个疗程h1、U、h3/h1有显著差异（P<0.05），治疗组h1、U值升高更明显，h3/h1降低更明显。结论：通过舌脉像客观化研究，进一步证明了益气清毒法能有效改善肺癌患者旳身体状况。舌脉象参数可作为指导肺癌中医治疗的有效指标之一，但仍需进一步大样本的临床验证。 |
| 英文摘要: |
| Objective: To analyze the dynamic changes of objective parameters of tongue and pulse in patients with advanced lung cancer after the intervention of TCM Yiqiqingdu, so as to provide reference for objective diagnosis and treatment of TCM. Methods: 100 patients with advanced lung cancer were randomly divided into treatment group (50 cases) and control Group (50 cases). The treatment group was treated with TCM Yiqiqingdu. The Control Group was treated with Western medicine. Both groups were treated for 4 courses. Tongue and pulse parameters were
collected before treatment, after 2 courses of treatment and 4 courses of treatment respectively. The changes of tongue and pulse parameters were observed during the treatment. Results: (1) Change of tongue parameters: Comparison between treatment groups: compared with before treatment, the dryness index, thickness index and greasy index of the patients after 2 courses of treatment all had significant changes(p<0.05);The dryness index, crack index, thickness index and greasy index of the patients had significant changes after 4 courses of treatment compared with those before treatment (P<0.05); The crack index and thickness index were significantly lower in 4 courses of treatment than in 2 courses of treatment(P<0.05). Comparison between control groups: Compared with before treatment, the dryness index, crack index and greasy index of the patients after 2 courses and 4 courses of treatment had significant changes(P<0.05);Compared with the 2 courses of treatment, the dryness index and crack index of 4 courses of treatment showed significant changes(P<0.05). Contrast between the two groups: The dryness index, thickness index, greasy index and crack index were significantly different between the two groups after 2 courses and 4 courses of treatment (P<0.05). (2) Change of pulse parameters：Treatment Group: Compared with pre-treatment, H1, U and P were significantly increased and h3/h1 were significantly decreased in patients with 2 courses of treatment and 4 courses of Treatment (P<0.05) , the changes of h 1, U and H 3/h 1 were significantly different (P<0.05) . Control Group: Compared with pre-treatment, h3/h1 of the patients after two courses of treatment was significantly lower (P<0.05) , H1, U and P were significantly higher and h3/h1 was significantly lower after four courses of treatment, the difference was statistically significant (P<0.05) , and U was significantly higher in 4 courses of treatment than in 2 courses of Treatment (P<0.05) . There was a significant difference in U value between the two groups (P<0.05) , the increase of u value in the treatment group was more obvious than that in the control group, there was a significant difference in h 1, U, H 3/h 1 in the four treatment courses (P<0.05) , the increase of U value in the treatment group was more obvious, the decrease in H3H1 was even more pronounced. Conclusion: Through the objective study of tongue and pulse images, it is further proved that the method of TCM Yiqiqingdu can effectively improve the physical condition of lung cancer patients.The parameters of tongue and pulse can be used as one of the effective indexes to guide the treatment lung cancer in Traditional Chinese medicine. But we still need further large-scale clinical validation. |
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