| 吴伟棋，杨娟，卢秀仪，黄娴，唐增奇.5-氨基酮戊酸光动力疗法治疗尖锐湿疣患者的疗效观察[J].实用中西医结合临床,2020,20(7):4-5,35 |
| 5-氨基酮戊酸光动力疗法治疗尖锐湿疣患者的疗效观察 |
| The Clinic Effect of Photodynamic Therapy with 5-Aminolevulinic Acid on Condyloma Acuminatum |
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| DOI： |
| 中文关键词: 尖锐湿疣 5-氨基酮戊酸光动力法 电离子手术 HPV6/11型DNA |
| 英文关键词: Condyloma acuminatum 5-Aminolevulinic acid Photodynamic therapy Electric ion operating HPV6/11-DNA |
| 基金项目:广州市增城区科技创新资金计划项目（ZCKJ2019-005）； 广东省医学科学技术研究基金项目（A2020433） |
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| 中文摘要: |
| 目的：分析5-氨基酮戊酸光动力疗法治疗尖锐湿疣患者的疗效观察。方法：选取2017年3月~2019年4月收治的尖锐湿疣患者58例作为研究对象，以随机数字表法分为对照组和治疗组，各29例。对照组予以电离子手术治疗，治疗组予以5-氨基酮戊酸光动力疗法治疗。比较两组总体治疗效果、治疗前后HPV6/11型DNA载量及复发情况。结果：治疗3个月后，治疗组HPV6/11型DNA载量低于对照组，差异有统计学意义（P＜0.05）；治疗组总有效率高于对照组，差异有统计学意义（P＜0.05）；治疗组总复发率低于对照组，差异有统计学意义（P＜0.05）。结论：采用5-氨基酮戊酸光动力疗法治疗尖锐湿疣患者，可降低患者HPV病毒载量，保证治疗效果实现最优化，降低复发率。 |
| 英文摘要: |
| Objective: To investigate the clinic effect of photodynamic therapy with 5-aminolevulinic acid on condyloma acuminatum. Methods: From March 2017 to April 2019, 58 admitted patients with condyloma acuminatum were selected as the study objects. They were divided into the control group and the treatment group with random number table method, with 29 cases in each group. The control group was treated with electric ion operation, the treatment group was given photodynamic therapy with 5-aminolevulinic acid. The overall clinic effects, loading amount of HPV6/11-DNA before and after treatment and recurrence of the two groups were compared. Results: After the treatment of 3 months, the loading amount of HPV6/11-DNA in the treatment group was lower than that in the control group, with statistical significance (P＜0.05); the total effective rate in the treatment group was higher than that in the control group, with statistical significance (P＜0.05); the total recurrence rate in the treatment group was lower than that in the control group, with statistical significance (P＜0.05). Conclusion: In the treatment of patients with condyloma acuminatum, loading amount of HPV was reduced, treatment effect was ensured and recurrence rate was reduced by 5-Aminolevulinic acid photodynamic therapy. |
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