校彦勇,王荣鑫,王琳.美沙拉嗪联合马来酸曲美布汀对肠易激综合征患者的影响[J].实用中西医结合临床,2020,20(01):1-2,70 |
美沙拉嗪联合马来酸曲美布汀对肠易激综合征患者的影响 |
The Effect of Mesalazine Combined with Trimebutin Maleate on Patients with Irritable Bowel Syndrome |
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DOI: |
中文关键词: 肠易激综合征 美沙拉嗪 马来酸曲美布汀 |
英文关键词: Irritable bowel syndrome Mesalazine Trimebutin maleate |
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中文摘要: |
目的:观察美沙拉嗪联合马来酸曲美布汀治疗肠易激综合征的临床效果。方法:选取2018年4月~2019年3月收治的肠易激综合征患者110例为研究对象,按随机数字表法分为甲组与乙组,各55例。甲组给予马来酸曲美布汀治疗,乙组给予美沙拉嗪+马来酸曲美布汀治疗。对比两组疗效、症状积分及细胞因子水平。结果:乙组治疗总有效率94.5%明显高于甲组的78.2%,差异有统计学意义(P<0.05);乙组黏液便、排便时腹胀、排便过程异常、排便性状异常、腹痛频率以及腹痛时间等症状积分明显低于甲组,差异有统计学意义(P<0.05);两组治疗前各细胞因子水平对比,差异无统计学意义(P>0.05);治疗后两组白介素-6、白介素-8及肿瘤坏死因子-?琢水平低于治疗前,且乙组治疗后白介素-6、白介素-8及肿瘤坏死因子-?琢水平低于甲组,差异有统计学意义(P<0.05)。结论:采用美沙拉嗪联合马来酸曲美布汀治疗肠易激综合征效果显著,可改善患者细胞因子水平,较快缓解患者各项临床症状。 |
英文摘要: |
Objective: To observe the clinical effect of mesalazine combined with trimebutin maleate in the treatment of irritable bowel syndrome. Methods: 110 patients with irritable bowel syndrome admitted from April 2018 to March 2019 were selected as the study objects. They were randomly divided into first group and second group, with 55 cases each. The first group was treated with trimebutin maleate, while the second group was treated with mesalazine and trimebutin maleate. Efficacy, symptom scores and Cytokine levels before and after treatment were compared between the two groups. Results: The total effective rate of the second group was 94.5%, higher than that of the first group which was 78.2% (P<0.05). The symptom scores of the second group were significantly lower than that of the first group in terms of mucus stool, abdominal distension during defecation, abnormal defecation process, abnormal defecation characteristics, frequency and duration of abdominal pain (P<0.05). There was no significant difference in Cytokine levels between the two groups before treatment (P>0.05). After treatment, the levels of IL-6, IL-8 and TNF-?琢 in two groups were lower than those before treatment, and the levels of IL-6, IL-8 and TNF-?琢 in the second group were lower than those in the first group (P<0.05). Conclusion: Mesalazine combined with trimebutin maleate was effective in the treatment of irritable bowel syndrome, the levels of Cytokine were improved and the clinical symptoms were relieved. |
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